Avocado, banana, and kiwi are common fruits that can trigger this response. Cross-Reactivity is the ability of an antibody to react with similar antigenic sites on different proteins. This cross-reactivity means that they may have to avoid certain foods and latex products. side chains between different beta-lactam antibiotics may be the source of cross-reactivity between penicillins and 1st and 2nd generation cephalosporins.
Piperacillin-tazobactam – Similarly, allergic reaction specific to tazobactam is rare but possible. People who have latex allergies often have a food allergy, typically to fruits that have proteins similar to those found in natural rubber latex. Consider penicillin skin-testing +/- amoxicillin challenge. Amoxicillin–clavulanate – patients who have a true IgE-mediated hypersensitivity to this drug combination may have an allergy to the clavulanate component, but not amoxicillin or other beta-lactam antibiotics. In these patients, use clinical judgement and caution when prescribing any new antimicrobial. NB: Be aware that some patients may react to other β-lactams not because of cross-reactivity but because of their underlying predisposition to develop allergic reactions to multiple unrelated drugs (multiple drug allergy syndrome). drug rash with eosinophilia & systemic symptoms (DRESS).Avoid all β-lactam antibiotics if documented severe non-lgE-mediated reaction to penicillin:
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